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dc.contributor.authorFreeman, J
dc.date.accessioned2024-03-01T13:10:25Z
dc.date.available2024-03-01T13:10:25Z
dc.date.issued2024-03-01
dc.identifier.issn1545-9683
dc.identifier.issn1552-6844
dc.identifier.urihttps://pearl.plymouth.ac.uk/handle/10026.1/22115
dc.description.abstract

Abstract Background: People with progressive multiple sclerosis (PMS) present motor (eg, walking) and cognitive impairments, and report fatigue. Fatigue encompasses fatigability which is objectively measured by the capacity to sustain a motor or cognitive task. Objective: To investigate the prevalence of walking and cognitive fatigability (CF) and the associated clinical characteristics in a large sample of PMS patients. Methods: PMS patients (25-65 years old) were included from 11 sites (Europe and North America), having cognitive impairment (1.28 standard deviation below normative data for the symbol digit modality test [SDMT]). Walking fatigability (WF) was assessed using the distance walk index (DWI) and CF using the SDMT (scores from the last 30 seconds compared to the first 30 seconds). Additional measures were: cognitive assessment—Brief International Cognitive Assessment for multiple sclerosis (MS), cardiorespiratory fitness, 6-minute walk, physical activity, depressive symptoms, perceived fatigue—Modified Fatigue Impact Scale (MFIS), MS impact—MSIS-29, and walking ability. Results: Of 298 participants, 153 (51%) presented WF (DWI = −28.9 ± 22.1%) and 196 (66%) presented CF (−29.7 ± 15%). Clinical characteristics (EDSS, disease duration, and use of assistive device) were worse in patients with versus without WF. They also presented worse scores on MSIS-29 physical, MFIS total and physical and reduced physical capacity. CF patients scored better in the MSIS-29 physical and MFIS psychosocial, compared to non-CF group. Magnitude of CF and WF were not related. Conclusions: Half of the cognitively-impaired PMS population presented WF which was associated with higher disability, physical functions, and fatigue. There was a high prevalence of CF but without strong associations with clinical, cognitive, and physical functions. Trial Registration Number: The “CogEx-study,” www.clinicaltrial.gov identifier number: NCT03679468.

dc.format.extent327-338
dc.format.mediumPrint-Electronic
dc.languageen
dc.publisherSage
dc.subjectcognition
dc.subjectfatigue
dc.subjectmultiple sclerosis
dc.subjectprogressive
dc.subjectwalking
dc.subjectAdult
dc.subjectAged
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectCognitive Dysfunction
dc.subjectFatigue
dc.subjectMultiple Sclerosis, Chronic Progressive
dc.subjectPrevalence
dc.subjectWalking
dc.titlePrevalence and associated clinical characteristics of walking-related motor, and cognitive, fatigability in progressive multiple sclerosis: baseline results from the CogEx study
dc.typejournal-article
dc.typeJournal Article
dc.typeResearch Support, Non-U.S. Gov't
dc.typeMulticenter Study
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38426484
plymouth.issue5
plymouth.volume38
plymouth.publisher-urlhttp://dx.doi.org/10.1177/15459683241236161
plymouth.publication-statusPublished
plymouth.journalNeurorehabilitation and Neural Repair
dc.identifier.doi10.1177/15459683241236161
plymouth.organisational-group|Plymouth
plymouth.organisational-group|Plymouth|Research Groups
plymouth.organisational-group|Plymouth|Faculty of Health
plymouth.organisational-group|Plymouth|Faculty of Health|School of Health Professions
plymouth.organisational-group|Plymouth|Research Groups|Institute of Health and Community
plymouth.organisational-group|Plymouth|REF 2021 Researchers by UoA
plymouth.organisational-group|Plymouth|Users by role
plymouth.organisational-group|Plymouth|Users by role|Academics
plymouth.organisational-group|Plymouth|REF 2021 Researchers by UoA|UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group|Plymouth|Users by role|Researchers in ResearchFish submission
plymouth.organisational-group|Plymouth|Research Groups|Plymouth Institute of Health and Care Research (PIHR)
plymouth.organisational-group|Plymouth|REF 2029 Researchers by UoA
plymouth.organisational-group|Plymouth|REF 2029 Researchers by UoA|UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
dc.publisher.placeUnited States
dcterms.dateAccepted2024-02-12
dc.date.updated2024-03-01T13:10:22Z
dc.rights.embargodate2024-3-9
dc.identifier.eissn1552-6844
rioxxterms.versionofrecord10.1177/15459683241236161


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