Peninsula Medical School: Recent submissions
Now showing items 121-130 of 1220
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JAK3 Inhibition Regulates Stemness and Thereby Controls Glioblastoma Pathogenesis
(MDPI AGSwitzerland, 2023-10-30)Glioblastoma multiforme (GBM) is the most deadly brain tumor, effective treatment options for which still remain elusive. The current treatment procedure of maximal resection followed by chemotherapy has proved to be ... -
Liquidity and uncertainty: digital adaptation of a complex intervention for people with severe mental illness during the COVID-19 lockdown
(Springer Science and Business Media LLC, 2023-08-03)Background This paper explores the extent to which the implementation and evaluation of a collaborative care model of face-to-face service delivery for people with severe mental illness was viable during the first UK ... -
Exploring recent patterns of migration of doctors to the United Kingdom: a mixed-methods study
(Springer Science and Business Media LLCEngland, 2023-11-04)Introduction A shortage of doctors is currently one of the biggest challenges faced by the healthcare workforce in the United Kingdom (UK). While plans are in place to increase the number of medical school places, in the ... -
Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests
(Springer Science and Business Media LLCEngland, 2023-08-26)Unlike for advanced liver fibrosis, the practical rules for the early non-invasive diagnosis of cirrhosis in NAFLD remain not well defined. Here, we report the derivation and validation of a stepwise diagnostic algorithm ... -
Open‐label, clinical trial extension: Two‐year safety and efficacy results of seladelpar in patients with primary biliary cholangitis
(WileyEngland, 2023-10-30)Background Seladelpar is a potent and selective peroxisome proliferator-activated receptor-δ agonist that targets multiple cell types involved in primary biliary cholangitis (PBC), leading to anti-cholestatic, anti-inflammatory ... -
Older peoples' lived experiences of personalised care in care homes: A meta‐ethnography
(WileyEngland, 2024-01)<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Guidance and policy on personalised (or person‐centred) care of older people living in care homes advocates that all residents must ... -
Exploring basic science knowledge retention within a cohort of undergraduate medical students in the United Kingdom: A longitudinal study
(WileyEngland, 2023-12-30)Background Clinical reasoning is reliant on students having acquired a strong foundation in the basic sciences. However, there remains uncertainty regarding whether medical students are maintaining this knowledge over the ... -
Phenotypic effect of GBA1 variants in individuals with and without Parkinson's disease: The RAPSODI study
(Elsevier BVUnited States, 2023-11)Background Variants in the GBA1 gene cause the lysosomal storage disorder Gaucher disease (GD). They are also risk factors for Parkinson's disease (PD), and modify the expression of the PD phenotype. The penetrance of ... -
Perceived confidence of dental students and new graduates in performing tooth extractions—An exploratory study
(WileyEngland, 2023-09-12)Introduction The ability to perform uncomplicated tooth extractions is a core clinical skill in undergraduate dental education. The aim of this study was to evaluate pre-extraction assessment skills of dental students and ... -
A programme evaluation of ‘First Steps’: A peer-conceived, developed and led self-management intervention for people after a Parkinson's diagnosis
(SAGE PublicationsEngland, 2023-11-09)ObjectiveA diagnosis of Parkinson's often leads to uncertainty about the future and loss of perceived control. Peer support may offer a means to address these concerns and promote self-management. DesignA programme ...
