Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

Towns, C; Richer, M; Jasaityte, S; Stafford, EJ; Joubert, J; Antar, T; Martinez-Carrasco, A; Makarious, MB; Casey, B; Vitale, D; Levine, K; Leonard, H; Pantazis, CB; Screven, LA; Hernandez, DG; Wegel, CE; Solle, J; Nalls, MA; Blauwendraat, C; Singleton, AB; Tan, MMX; Iwaki, H; Morris, HR; Gatto, EM; Kauffman, M; Khachatryan, S; Tavadyan, Z; Shepherd, CE; Hunter, J; Kumar, K; Ellis, M; Rentería, ME; Koks, S; Zimprich, A; Schumacher-Schuh, AF; Rieder, C; Awad, PS; Tumas, V; Camargos, S; Fon, EA; Monchi, O; Fon, T; Galleguillos, BP; Miranda, M; Bustamante, ML; Olguin, P; Chana, P; Tang, B; Shang, H; Guo, J; Chan, P; Luo, W; Arboleda, G; Orozco, J; del Rio, MJ; Hernandez, A; Salama, M; Kamel, WA; Zewde, YZ; Brice, A; Corvol, J-C; Westenberger, A; Illarionova, A; Mollenhauer, B; Klein, C; Vollstedt, E-J; Hopfner, F; Höglinger, G; Madoev, H; Trinh, J; Junker, J; Lohmann, K; Lange, LM; Sharma, M; Groppa, S; Gasser, T; Fang, Z-H; Akpalu, A; Xiromerisiou, G; Hadjigorgiou, G; Dagklis, I; Tarnanas, I; Stefanis, L; Stamelou, M; Dadiotis, E; Medina, A; Chan, GH-F; Ip, N; Cheung, NY-F; Chan, P; Zhou, X; Kishore, A; KP, D; Pal, P; Kukkle, PL; Rajan, R; Borgohain, R; Salari, M; Quattrone, A; Valente, EM; Parnetti, L; Avenali, M; Schirinzi, T; Funayama, M; Hattori, N; Shiraishi, T; Karimova, A; Kaishibayeva, G; Shambetova, C; Krüger, R; Tan, AH; Ahmad-Annuar, A; Norlinah, MI; Murad, NAA; Azmin, S; Lim, S-Y; Mohamed, W; Tay, YW; Martinez-Ramirez, D; Rodriguez-Violante, M; Reyes-Pérez, P; Tserensodnom, B; Ojha, R; Anderson, TJ; Pitcher, TL; Sanyaolu, A; Okubadejo, N; Ojo, O; Aasly, JO; Pihlstrøm, L; Tan, M; Ur-Rehman, S; Cornejo-Olivas, M; Doquenia, ML; Rosales, R; Vinuela, A; Iakovenko, E; Mubarak, BA; Umair, M; Tan, E-K; Foo, JN; Amod, F; Carr, J; Bardien, S; Jeon, B; Kim, YJ; Cubo, E; Alvarez, I; Hoenicka, J; Beyer, K; Periñan, MT; Pastor, P; El-Sadig, S; Zweier, C; Krack, P; Lin, C-H; Wu, H-C; Kung, P-J; Wu, R-M; Wu, Y; Amouri, R; Sassi, SB; Başak, AN; Genc, G; Çakmak, ÖÖ; Ertan, S; Noyce, A; Schrag, A; Schapira, A; Carroll, C; Bale, C; Grosset, D; Houlden, H; Hardy, J; Mok, KY; Rizig, M; Wood, N; Williams, N; Okunoye, O; Lewis, PA; Kaiyrzhanov, R; Weil, R; Love, S; Stott, S; Jasaitye, S; Dey, S; Obese, V; Espay, A; O’Grady, A; Sobering, AK; Siddiqi, B; Fiske, B; Jonas, C; Cruchaga, C; Comart, C; Wegel, C; Hall, D; Hernandez, D; Shiamim, E; Riley, E; Faghri, F; Serrano, GE; Chen, H; Mata, IF; Sarmiento, IJK; Williamson, J; Kim, JJ; Jankovic, J; Shulman, J; Solle, JC; Murphy, K; Nuytemans, K; Kieburtz, K; Markopoulou, K; Marek, K; Levine, KS; Chahine, LM; Ibanez, L; Screven, L; Ruffrage, L; Shulman, L; Marsili, L; Kuhl, M; Dean, M; Koretsky, M; Puckelwartz, MJ; Inca-Martinez, M; Louie, N; Mencacci, NE; Albin, R; Alcalay, R; Walker, R; Bandres-Ciga, S; Chowdhury, S; Dumanis, S; Lubbe, S; Xie, T; Foroud, T; Beach, T; Sherer, T; Song, Y; Nguyen, D; Nguyen, T; Atadzhanov, M

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Date

2023-09-12

Author

Towns, C

Richer, M

Jasaityte, S

Stafford, EJ

Joubert, J

Antar, T

Martinez-Carrasco, A

Makarious, MB

Casey, B

Vitale, D

Levine, K

Leonard, H

Pantazis, CB

Screven, LA

Hernandez, DG

Wegel, CE

Solle, J

Nalls, MA

Blauwendraat, C

Singleton, AB

Tan, MMX

Iwaki, H

Morris, HR

Gatto, EM

Kauffman, M

Khachatryan, S

Tavadyan, Z

Shepherd, CE

Hunter, J

Kumar, K

Ellis, M

Rentería, ME

Koks, S

Zimprich, A

Schumacher-Schuh, AF

Rieder, C

Awad, PS

Tumas, V

Camargos, S

Fon, EA

Monchi, O

Fon, T

Galleguillos, BP

Miranda, M

Bustamante, ML

Olguin, P

Chana, P

Tang, B

Shang, H

Guo, J

Chan, P

Luo, W

Arboleda, G

Orozco, J

del Rio, MJ

Hernandez, A

Salama, M

Kamel, WA

Zewde, YZ

Brice, A

Corvol, J-C

Westenberger, A

Illarionova, A

Mollenhauer, B

Klein, C

Vollstedt, E-J

Hopfner, F

Höglinger, G

Madoev, H

Trinh, J

Junker, J

Lohmann, K

Lange, LM

Sharma, M

Groppa, S

Gasser, T

Fang, Z-H

Akpalu, A

Xiromerisiou, G

Hadjigorgiou, G

Dagklis, I

Tarnanas, I

Stefanis, L

Stamelou, M

Dadiotis, E

Medina, A

Chan, GH-F

Ip, N

Cheung, NY-F

Chan, P

Zhou, X

Kishore, A

KP, D

Pal, P

Kukkle, PL

Rajan, R

Borgohain, R

Salari, M

Quattrone, A

Valente, EM

Parnetti, L

Avenali, M

Schirinzi, T

Funayama, M

Hattori, N

Shiraishi, T

Karimova, A

Kaishibayeva, G

Shambetova, C

Krüger, R

Tan, AH

Ahmad-Annuar, A

Norlinah, MI

Murad, NAA

Azmin, S

Lim, S-Y

Mohamed, W

Tay, YW

Martinez-Ramirez, D

Rodriguez-Violante, M

Reyes-Pérez, P

Tserensodnom, B

Ojha, R

Anderson, TJ

Pitcher, TL

Sanyaolu, A

Okubadejo, N

Ojo, O

Aasly, JO

Pihlstrøm, L

Tan, M

Ur-Rehman, S

Cornejo-Olivas, M

Doquenia, ML

Rosales, R

Vinuela, A

Iakovenko, E

Mubarak, BA

Umair, M

Tan, E-K

Foo, JN

Amod, F

Carr, J

Bardien, S

Jeon, B

Kim, YJ

Cubo, E

Alvarez, I

Hoenicka, J

Beyer, K

Periñan, MT

Pastor, P

El-Sadig, S

Zweier, C

Krack, P

Lin, C-H

Wu, H-C

Kung, P-J

Wu, R-M

Wu, Y

Amouri, R

Sassi, SB

Başak, AN

Genc, G

Çakmak, ÖÖ

Ertan, S

Noyce, A

Schrag, A

Schapira, A

Carroll, C

Bale, C

Grosset, D

Houlden, H

Hardy, J

Mok, KY

Rizig, M

Wood, N

Williams, N

Okunoye, O

Lewis, PA

Kaiyrzhanov, R

Weil, R

Love, S

Stott, S

Jasaitye, S

Dey, S

Obese, V

Espay, A

O’Grady, A

Sobering, AK

Siddiqi, B

Fiske, B

Jonas, C

Cruchaga, C

Comart, C

Wegel, C

Hall, D

Hernandez, D

Shiamim, E

Riley, E

Faghri, F

Serrano, GE

Chen, H

Mata, IF

Sarmiento, IJK

Williamson, J

Kim, JJ

Jankovic, J

Shulman, J

Solle, JC

Murphy, K

Nuytemans, K

Kieburtz, K

Markopoulou, K

Marek, K

Levine, KS

Chahine, LM

Ibanez, L

Screven, L

Ruffrage, L

Shulman, L

Marsili, L

Kuhl, M

Dean, M

Koretsky, M

Puckelwartz, MJ

Inca-Martinez, M

Louie, N

Mencacci, NE

Albin, R

Alcalay, R

Walker, R

Bandres-Ciga, S

Chowdhury, S

Dumanis, S

Lubbe, S

Xie, T

Foroud, T

Beach, T

Sherer, T

Song, Y

Nguyen, D

Nguyen, T

Atadzhanov, M

Subject

Global Parkinson’s Genetics Program (GP2)

Metadata

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Abstract

The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.

Publisher

Springer Science and Business Media LLC

Place of Publication

United States

Journal

npj Parkinson's Disease

Volume

Issue

Pagination

131-

Author URL

https://www.ncbi.nlm.nih.gov/pubmed/37699923

Publisher URL

http://dx.doi.org/10.1038/s41531-023-00533-w

Number

131

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