Peninsula Medical School: Recent submissions
Now showing items 11-20 of 1220
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Review of Evidence on Implementation in Education
(Education Endowment FoundationLondon, 2024-04-24) -
Anti-stigma interventions in low-income and middle-income countries: a systematic review
(Elsevier BV, 2024-06)Background Stigma exacerbates power imbalances and societal disparities, significantly impacting diverse identities and health conditions, particularly for low and middle-income countries (LMICs). Though crucial for ... -
A pragmatic, multicentre, double-blind, placebo-controlled randomised trial to assess the safety, clinical and cost-effectiveness of mirtazapine and carbamazepine in people with Alzheimer’s disease and agitated behaviours: the HTA-SYMBAD trial
(National Institute for Health and Care ResearchEngland, 2023-10)Background: Agitation is common and impacts negatively on people with dementia and carers. Non-drug patient-centred care is first-line treatment, but we need other treatment when this fails. Current evidence is sparse on ... -
Implementation of large, multi-site hospital interventions: a realist evaluation of strategies for developing capability
(Springer Science and Business Media LLCEngland, 2024-03-06)Background This study presents guidelines for implementation distilled from the findings of a realist evaluation. The setting was local health districts in New South Wales, Australia that implemented three clinical ... -
The Mental Wellbeing of Child and Adolescent Mental Health Service (CAMHS) Workers in England: A Cross-Sectional Descriptive Study Reporting Levels of Burnout, Wellbeing and Job Satisfaction
(MDPI AGSwitzerland, 2024-02-07)In the UK, there has been a notable increase in referrals to specialist children’s mental health services. This, coupled with shortages of qualified staff, has raised concerns about the escalating occupational stress ... -
Pharmacokinetics of propofol in severely obese surgical patients
(WileyEngland, 2024-03-13)Background Existing PK models of propofol include sparse data from very obese patients. The aim of this study was to develop a PK model based on standardised surgical conditions and spanning from normal-weight up to, and ... -
A dominant-negative regulatory mechanism of SQSTM1 droplets-based autophagy
(Informa UK LimitedUnited States, 2022-04-03)SQSTM1/p62 is an autophagy receptor, forming droplets to sequester intracellular polyubiquitinated cargo and mediate its delivery for autophagic clearance. SQSTM1 droplets can function as platforms to allow the formation ... -
Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
(Elsevier BVUnited States, 2024-03-26)Autophagy and ribonucleoprotein granules, such as P-bodies (PBs) and stress granules, represent vital stress responses to maintain cellular homeostasis. SQSTM1/p62 phase-separated droplets are known to play critical roles ... -
Ethnic Inequalities in Sentencing: Evidence from the Crown Court in England and Wales
(Oxford University Press (OUP), 2024)<jats:title>Abstract</jats:title> <jats:p>In recent years, there has been considerable policy and academic interest in the existence of ethnic inequalities in the Criminal Justice System. A large body of ... -
Perioperative oxygenation-what's the stress?
(Elsevier BVEngland, 2024-06)Oxygen is the most used drug in anaesthesia. Despite such widespread use, optimal perioperative oxygen administration remains highly controversial because of concerns about the competing harms of both hyperoxia and hypoxia. ...
