Peninsula Medical School: Recent submissions
Now showing items 21-30 of 1220
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The barriers to and facilitators of implementing early mobilisation for patients with delirium on intensive care units: A systematic review
(SAGE PublicationsEngland, 2024-05)<jats:sec><jats:title>Background:</jats:title><jats:p> Early mobilisation of critically ill patients remains variable across practice. This study set out to determine barriers to and facilitators of early mobilisation for ... -
Lowering Mutant Huntingtin Levels and Toxicity: Autophagy-Endolysosome Pathways in Huntington's Disease
(Elsevier BVNetherlands, 2020-04)Huntington's disease (HD) is a monogenetic neurodegenerative disease, which serves as a model of neurodegeneration with protein aggregation. Autophagy has been suggested to possess a great value to tackle protein aggregation ... -
Making progression and award decisions.
(2017-01)This article was migrated. The article was marked as recommended. It is incumbent on medical schools to show, both to regulatory bodies and to the public at large, that their graduating students are "fit for purpose" as ... -
How to facilitate NHS professionals to recognise and use skills gained from global health engagement when back in the UK workforce? A participatory action research project to design, pilot and evaluate a series of online leadership workshops
(BMJEngland, 2024-03)<jats:sec><jats:title>Objectives</jats:title><jats:p>Leadership knowledge and skills are known to be developed by health professionals during global health experiences overseas. However, volunteers struggle to recognise ... -
Transformation of autophagic SQSTM1 droplets to SQSTM1-dependent P-bodies
(Informa UK LimitedUnited States, 2024)SQSTM1/p62 droplets play crucial roles in droplets-based macroautophagy/autophagy including selective autophagy and bulk autophagy. We observed that under several stress milieus, SQSTM1 droplets entirely colocalize with ... -
Histone H3F3/H3.3 chaperone DAXX converts to modulate SQSTM1 phase condensation for NFE2L2 activation
(Informa UK LimitedUnited States, 2020-01-02)Macroautophagy/autophagy cargo receptor SQSTM1/p62 puncta or clustering formation is critical for its function in cargo recognition and LC3 interaction. Evidence suggests that SQSTM1 puncta formation is a process of ... -
Standard setting anchor statements: a double cross-over trial of two different methods.
(2021-01)This article was migrated. The article was marked as recommended. Context: We challenge the philosophical acceptability of the Angoff method, and propose an alternative method of standard setting based on how important ... -
Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care: Protocol for the UK-ROX trial
(SAGE PublicationsEngland, 2024)Background: In the United Kingdom, around 184,000 adults are admitted to an intensive care unit (ICU) each year with over 30% receiving mechanical ventilation. Oxygen is the commonest therapeutic intervention provided to ... -
Adult brain tumour research in 2024: Status, challenges and recommendations
(WileyEngland, 2024-04-11)In 2015, a groundswell of brain tumour patient, carer and charity activism compelled the UK Minister for Life Sciences to form a brain tumour research task and finish group. This resulted, in 2018, with the UK government ... -
Unraveling the CLCC1 interactome: Impact of the Asp25Glu variant and its interaction with SigmaR1 at the Mitochondrial-Associated ER Membrane (MAM).
(Elsevier BVIreland, 2024-05-01)The endoplasmic reticulum (ER) plays an indispensable role in cellular processes, including maintenance of calcium homeostasis, and protein folding, synthesized and processing. Disruptions in these processes leading to ...
